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Radiochemistry

ReDIB offers radiochemistry services in both nodes. The Molecular and Functional Imaging Facility of CIC biomaGUNE provides a radiochemistry lab equipped with a cyclotron, hot cells housing automatic synthesis modules and state of art quality control equipment. The Infrastructure for Translational Advanced Imaging has a radiochemical laboratory with shielded areas, a 68Ge/68Ga generator associated with an automatic synthesis module and fully equipped organic chemistry labs.

CIC biomaGUNE has a radiochemistry laboratory equipped with 5 shielded hot cells housing versatile automatic synthesis, suitable for the production (synthesis, purification and quality control) of PET and SPECT radiotracers. The facility has specially designed modules for:
 
  • Synthesis of [11C] CH3I / [11C] CH3OTf from [11C] CO2 / [11C] CH4, and subsequent methylation reaction
  • 18F-fluorination by nucleophilic and electrophilic substitution
  • Radiotracer synthesis using microfluidics technology
  • Chelation reactions using radiometals (68Ga, 67Ga, 64Cu, 89Zr, etc)

In addition, the laboratory has two shielded hot cells for manual handling of radioactive substances, suitable for the preparation of mono-doses or to perform syntheses with small amounts of radioactivity.

The quality control lab, sited into the production lab, is equipped with state of art equipment to perform the complete quality control of the synthesized radiotracers, including the following equipment.

Additionally, CNIC has a radiochemistry/nanochemistry lab which includes a relaxometer of 1.5 Tesla, nanosizer ZS-90, homogenizer, 68Ga generator and a synthesis module equipped with an organic chemistry lab.

 

Cyclotron

The cyclotron is able to accelerate protons (18 MeV) and deuterons (9 MeV) and is equipped with 7 targets for the routine production of [18F] F-, [18F]-F2, [13N]-NH4+-, [15O]-O2 [11C]-CO2 and [11C]-CH4. It also has a solid target for the production of 89Zr and 64Cu.

Location: CIC biomaGUNE

Hot Cells

Hot cells (75 mm lead) front and rear opening and two laminar flow sinkers equipped with gas compression system.Location: CIC biomaGUNE

Synthesis Modules

Remotely controlled automatic modules specially designed to carry out methylation reactions, fluorination by electrophilic/nucleophilic substitution reactions and microfluidics.Location: CIC biomaGUNE

Radio-thin layer chromatography (radio-TLC)

Location: CIC biomaGUNE

High-resolution λ Spectrometer

30 mm thick Germanium detector. Energy range from 3 to 3000 keV. High energy resolution, ranging from 700 eV to 1.3 keV. Equipped with Mone Carlo-based quantification software.Location: CIC biomaGUNE

Low resolution multichannel λ spectrometry

Measures very small amounts of sodium iodide, and to perform radioimmunoassays. Storage capacity of 55 racks; 10 simultaneous measurements in the range 15-1000 keV.Location: CIC biomaGUNE

Gas chromatography (GC)

With flame ionization detector (FID), mass spectrometry (MS) and radiometric detection.Location: CIC biomaGUNE

High performance liquid chromatography (HPLC)

With UV (DAD, variable λ) and radiometric (well coincidence) detectors.Location: CIC biomaGUNE

Hot cells

Hot cells (75 mm lead), provided with front and rear opening, and with auxiliary elements for radiological protection (laminar flow booths, waste and transportation containers, protective screens, ventilation chambers, etc.)Location: BioImaC

Cyclotrón Cyclone 18/9 IBS

Able to accelerate protons up to a nominal energy of 18 MeV. Equipped with two liquid targets (IBA-2XL) for the production of 18F.

Location: BioImaC

Radiopharmaceutical synthesis modules

Located in the hot cells there are remotely controlled synthesis modules that allow the production, through organic nucleophilic substitution reactions, of 18F-FDG, 18F-FLT, 18F-FMISO, 18F-FDOPA, etc.

Location: BioImaC

ReDIB offers among its services the preparation of radiotracers for use in experimental animals (see table below) *. Customized synthesis services are also available.